Temporary or permanent loss of milk production,

Poor milk quality,

Discarding of milk from affected animals prior to or after antibiotic treatment pre-mature Segregating & Removing of the cow or reduced productive life of animals.

Mastitis affects the reproduction efficiency of the animals also, especially during early lactation period.

Mastitis delays the postpartum ovarian function and alters some of the key reproductive functions like ovulation, fertilization, implantation, and pregnancy maintenance.

Acute mastitis delays the calving to first service interval, calving to conception interval and increase the number of services per conception.

The probability of conception decreased by 44 per cent when mastitis occurred a week before insemination, by 73 per cent when it occurred during the week of insemination, and by 52 per cent when mastitis occurred during the week after insemination

Bacterial toxins released during mastitis influence conception and early embryonic survival in affected cattle by stimulating the production of prostaglandin F2α, which subsequently causes luteal regression, thus potentially causing the loss of an established pregnancy

The developing foetus, since the daughters born to the cows that suffered mastitis during gestation had reduced reproductive efficiency. Mastitis in pregnant cows could decrease the number of healthy follicles in the developing foetus and compromise future fertility.

Anti-Mullerian hormone, a reliable biomarker for potential fertility, is severely decreased in the developing foetus as the number of mastitis events during gestation of their dams increases